The gastrointestinal tract is a complex environment. Multidrug-resistant bacteria reside in our gut creating difficult to treat reservoirs of antibiotic resistant pathogens. Our work has led us to understand a major barrier phage have to overcome in order to infect and kill in the gut—the mucus layer. By utilizing gut-specific phages that can overcome this barrier we can potentially remove these bacterial reservoirs to prevent infections.
Due to the need we saw in the community our group has worked to create a service center at Baylor College of Medicine, TAILΦR (Tailored Antibacterials and Innovative Laboratories for phage (Φ) Research), that develops phage therapy treatments for patients with challenging antibiotic resistance infections. We want to spread the word about TAILΦR and potentially connect with phage researchers to create a community where we can work together to save lives.
Green, S. I. et al. Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract. bioRxiv 2020.07.20.212829 (2020) doi:10.1101/2020.07.20.212829.
Terwilliger, A. L. et al. Tailored Antibacterials and Innovative Laboratories for Phage (Φ) Research: Personalized Infectious Disease Medicine for the Most Vulnerable At-Risk Patients. PHAGE (2020) doi:10.1089/phage.2020.0007.