Welcome to PHAVES!

During the pandemic, we heard from many of you that you were missing out on hearing about each other's phage work, and missing talking to your fellow phage researchers and developers! So we started a series of virtual phage events in 2020 called PHAVES.

We like to experiment with a range of formats, including seminars, AMAs, interviews, panels and more! Plus, we love to incorporate opportunities to meet and chat with other phage enthusiasts.

Event recordings: Most events are recorded and shared in Capsid & Tail and on YouTube after the fact. (Prospective speakers, let us know anytime if this will be an issue for you). Videos are posted on our Youtube channel: https://phage.directory/youtube

Event summaries: Event summaries are written up and published in Capsid & Tail, our weekly newsletter, usually the third week of each month. Sign up to receive it here: https://phage.directory/capsid

Subscribe to our PHAVES Events Series

Our events occur approximately every month, and we will email you the details the day of the event. Remembering to sign up for every event can get tedious, so you can just sign up here if you'd like to get updates for every event! (If it gets to be too much, unsubscribing is easy).

Once you're signed up, event details will be sent the day of each event.

Upcoming PHAVES

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Freedom from antibiotic purgatory?: Salvage phage therapy for cure of spinal hardware infection

Date:

May 12, 2pm Mountain Time

An elderly female patient with progressively worsening chronic low back pain presented to the University of Colorado Hospital for a challenging spinal fixation surgery in the Summer 2020.   In the weeks that followed, her course was complicated by tissue dehiscence along the spinal surgical incision with underlying vertebral osteomyelitis secondary to Pseudomonas aeruginosa hardware infection.  Given the patient’s age and history of cerebral vascular aneurysms, her medical team determined that she was a poor candidate for oral quinolone suppression therapy of the hardware infection.  No longer a surgical candidate and unwilling to spend her life on chronic intravenous antibiotic therapy, the patient faced the decision of hospice versus experimental phage therapy.  Bravely, she chose the latter.  In partnership with collaborators at Yale University, we detail our successful single patient experience of phage therapy against P. aeruginosaspinal hardware infection.  If the outcome were to hold, to the best of our knowledge, this case would represent the first cure of a spinal hardware infection with salvage phage therapy.

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Details for individual events will be sent out right before the event starts.

Laura Damioli, MD Profile Image

Laura Damioli, MD

Assistant Professor Infectious Diseases, Director, Orthopedic Infectious Diseases | University of Colorado Denver

Greg Canfield, MD, PhD Profile Image

Greg Canfield, MD, PhD

ID Fellow, PGY6 | Division of Infectious Diseases, CU Anschutz

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Viral Host Range Database, an online tool for recording, analyzing and disseminating virus-host interactions

Date:

May 18, 5pm CEST (Paris time)

Viruses are ubiquitous and often infect more than one host. Since decades, hundreds of scientists have performed experiments to characterize the host range of bacteriophages. The number of these experiments has dramatically increased the past few years because of the revived interest for phage therapy. However, results from these interaction tests are rarely published under an exploitable format easily accessible to the community.

We conceived the viral host range database (VHRdb, https://viralhostrangedb.pasteur.cloud//) as an online resource that centralizes experimental host range data. The VHRdb is a unique tool that allows users to identify suitable hosts for a given virus and conversely a list of viruses infecting specific hosts. Moreover, independent sets of data can be compared to generate, visualize and rank outputs.

The VHRdb is open to contribution by any user upon registration. Contributed data are public or can remain private until publication, if any. Links to publications and sequence identifiers can be implemented, when available. Initiated from data obtained from interaction tests between bacteriophages and bacteria, the design of the VHRdb is compatible with viruses infecting all living forms.

The VHRdb represents a unique resource for the community to rapidly find or disseminate the range of hosts suitable for a virus, an information that can have broad interest for educational, scientific, medical and applied purposes.

Here is the link to the associated publication:

https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btab070/6140780

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Details for individual events will be sent out right before the event starts.

Quentin Lamy-Besnier  Profile Image

Quentin Lamy-Besnier

PhD Candidate at Institut Pasteur in Dr. Laurent Debarbieux’s Bacteriophage, Bacterium Host laboratory

Previous PHAVES

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Interview with Dr. Randy Fish on successfully treating diabetic foot wounds with phages

Dr. Randy Fish, DPM Profile Image

Dr. Randy Fish, DPM

Podiatrist in chronic wound healing and clinical research using bacteriophage in diabetic foot infections, Tacoma Diabetic Foot Clinic and PhageBiotics Research Foundation

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Jack of all strains, master of none? Host range and efficacy in phages of a phytopathogenic bacterium

Clara Torres-Barceló Profile Image

Clara Torres-Barceló

Plant Pathology Unit, INRAE, Avignon, France

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Phage Therapy: The Australian Experience

Jonathan Iredell Profile Image

Jonathan Iredell

Senior Infectious Diseases Specialist at the Westmead Institute for Medical Research, Sydney, Australia

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Phages as a teaching tool, and stories from 60 years of phage

Betty Kutter Profile Image

Head of the phage biology lab and professor emeritus at the Evergreen State College

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2021 Kickoff party!

Stephanie Lynch Profile Image

Volunteer PHAVES Coordinator

Jessica Sacher Profile Image

Co-founder of Phage Directory

Jan Zheng Profile Image

Co-founder of Phage Directory

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Learning How to Engineer Genomes by Building Phage

Paul Jaschke Profile Image

Assistant Professor at Macquarie University, Sydney, Australia, and CSO of Hyperdrive Science

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Up scaling phage production in a small biotech company

Emma Bell Profile Image

Principle Bacteriophage Scientist at Fixed Phage

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The potential of phage therapy in aquaculture

Panos Kalatzis Profile Image

Post-doctoral researcher at the University of Copenhagen, and co-founder of Aquatic Biologicals

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TAILORing Phage Therapy for the Gut and Beyond

Sabrina Green Profile Image

Maresso Lab, Baylor College of Medicine, Houston, TX, United States Tailor Service Center, Houston, TX, United States

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Boosting phage exploration by Artificial Intelligence: what could data science do for your research?

Piotr Tynecki Profile Image

R&D Manager, AI Software Engineer , PhD student. PhageAI co-creator, Phages2050 promoter. @ptynecki

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Virtual phage series kick-off party: Welcome to PHAVES!

Jessica Sacher Profile Image

Co-founder of Phage Directory

Jan Zheng Profile Image

Co-founder of Phage Directory

Present, or suggest a speaker, topic!

Do you have a topic in mind or a person you'd love to hear from? (Eg. I'd like to hear Betty Kutter give an overview of the history of phage therapy; or, I'd like to hear phage therapy biotech companies discuss how they're designing their clinical trials).

Submit your nominations on Slack: https://phage.directory/slack

Email us at: [email protected]

Or sign up to speak below:

Sign Up to Present

[October 2020 Update]: Our seminar schedule for 2020 is full, but we are considering If launching PHAVES Season 2 for 2021. If you're interested in presenting your research or your company's products in 2021, please sign up below. We'll get in touch to chat about the best format, length, and specifics.

Credits

PHAVES is brought to you thanks to the hard work of the following individuals!

Jessica Sacher Profile Image

Co-founder of Phage Directory

Stephanie Lynch Profile Image

Volunteer PHAVES Coordinator

Jan Zheng Profile Image

Co-founder of Phage Directory